Rejuran i at RE:BERRY Gangnam Seoul
Rejuran i Gangnam Seoul at RE:BERRY for 2cc. Under-eye skin is only 0.3-0.5mm thick (versus 1.5-2.0mm facial skin) and demands a specialized Rejuran i formula rather than standard skin boosters that form visible papules. Rejuran i delivers 50-1500 kDa salmon-derived polynucleotides into the periorbital dermis for 18-24% under-eye thickening and vascular transparency reduction. Dr. Yoon-Gon Ryu personally performs all Rejuran i injections using 32G ultra-thin needles with 60-90 minute consultations and 40-60 precision points per eye. 2 minutes from Gangnam Station Exit 10, open 365 days, 8 languages supported.
What is Rejuran i at RE:BERRY Gangnam?
Rejuran i at RE:BERRY Gangnam Seoul is a low-viscosity periorbital polynucleotide (PN) skin booster designed for the thin 0.5 mm under-eye dermis, for 2cc. Dr. Yoon-Gon Ryu personally performs 40–60 physician-only micro-injections per eye across a 3-session protocol spaced 3–4 weeks apart. The clinic is open 365 days, supports 8 languages, and is 2 minutes from Gangnam Station Exit 10 inside KI Tower B1–B2.
Rejuran i (also called Rejuran I) is a distinct formulation from Rejuran Healer or Rejuran HB: the viscosity is lowered so the product flows smoothly through 33G needles into the delicate periorbital dermis without bumping. This makes it the dedicated under-eye option in the Rejuran family.
RE:BERRY Gangnam pairs every Rejuran i session with a pre-numbing cream, cold-compress protocol, and physician-guided injection-density map. Each patient sees genuine sealed Pharma Research Bio product with the batch label on request.
Rejuran i Packages at RE:BERRY Gangnam
All prices include VAT. Your exact quote is confirmed at an in-person consultation.
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Rejuran i Before and After at RE:BERRY Gangnam
Actual patient results from RE:BERRY Gangnam. Individual outcomes may vary.
How Rejuran i Under-Eye PDRN Works at RE:BERRY Gangnam
A precision 4-step protocol designed for the 0.3-0.5mm thin periorbital dermis.
60-90 Minute Periorbital Skin Assessment
Dr. Yoon-Gon Ryu spends 60-90 minutes evaluating under-eye skin thickness with 22 MHz ultrasound (baseline 0.3-0.5mm), dark circle vascular scoring (type I pigmented, II vascular, III structural), fine line depth, and tear-trough anatomy. Rejuran i Gangnam Seoul protocols calibrate dose (2cc versus 4cc), injection point density (40-60 per eye), and depth (1.5mm dermal only, never below orbital rim). Patients combining with Potenza RF microneedling receive additional collagen assessment for full-face planning.
30-40 Minute Topical Numbing Protocol
A lidocaine 9.6% + prilocaine 2.4% topical anesthetic is applied under occlusion to the periorbital zone for 30-40 minutes, reducing Rejuran i injection discomfort by 75-85% on the visual analog scale. Eyelid skin is cleansed with chlorhexidine 0.5% and alcohol-free antiseptic away from the ocular surface. For combined Rejuran i Gangnam Seoul + Aqua Peel ( 000 add-on) sessions, deep pore cleansing is performed before numbing to optimize absorption.
40-60 Precision Points per Eye at 1.5mm Depth
Dr. Ryu performs 40-60 micro-injections per eye in a 0.5-0.8cm grid pattern, covering the tear-trough, lateral canthus, and infraorbital zones. Each deposit releases 0.01-0.02ml of Rejuran i low-viscosity solution at 1.5mm dermal depth — delivering 50-1500 kDa salmon PDRN to periorbital fibroblasts without crossing into fat pads. The precision technique takes 10-15 minutes per eye and uses 32G ultra-thin needles. Patients who want comprehensive rejuvenation add Signature Hydra Glow Package for full-face hydration.
15-Minute LDM Ultrasound + Cryo Recovery Mask
LDM (Local Dynamic Micro-massage) ultrasound at 3-10 MHz is applied for 10 minutes to disperse Rejuran i solution evenly across the periorbital dermis, reduce micro-swelling by 45%, and shorten papule visibility from 72 to 36 hours. A 4-6°C cryo hydrogel eye mask with growth factors is applied for 10 minutes. Total Rejuran i Gangnam Seoul session time is 85-100 minutes. Aftercare kit includes ceramide eye cream, SPF 50+, and 8-language recovery instructions. Next session recommended at 2-4 weeks.
What to Expect from Rejuran i Under-Eye PDRN
- Periorbital-Specific Low-Viscosity Formula Rejuran i uses a reformulated 50-1500 kDa PDRN solution with 30-40% lower viscosity than standard Rejuran Healer — calibrated specifically for the 0.3-0.5mm thin under-eye dermis. This spreads evenly without creating the visible papules that regular skin boosters produce in the periorbital zone.
- 18-24% Under-Eye Thickening at 12 Weeks Korean ultrasound studies show Rejuran i treatment produces 18-24% increase in periorbital dermal thickness at 12 weeks post-3-session protocol. This directly reduces the vascular transparency that causes 65-70% of dark circles by restoring dermal opacity over subdermal vessels.
- Addresses Type II Vascular Dark Circles Rejuran i Gangnam Seoul is particularly effective for Type II vascular dark circles caused by thin periorbital skin revealing underlying blood vessels. PDRN’s angiogenesis-normalizing effect and collagen-thickening cascade work together to mask vascular transparency — a mechanism that concealer and topical products cannot replicate.
- 6-10 Month Cumulative Results After a 3-session protocol of Rejuran i at monthly intervals, measurable periorbital thickness and dark circle reduction sustain for 6-10 months before maintenance is needed. Annual top-ups of 2 sessions maintain peak under-eye thickness and vascular masking for long-term benefit.
- 24-48 Hour Papule Downtime Tiny bumps (papules) at the 40-60 per-eye injection points flatten within 24-48 hours due to Rejuran i’s lower-viscosity formulation. 80% of RE:BERRY Gangnam Rejuran i patients experience zero bruising. Makeup can be applied after 24 hours and travelers return to work the same day.
- Safe for All Skin Types Including Skin of Color Rejuran i has been safely studied in Fitzpatrick IV-VI skin types with no post-inflammatory hyperpigmentation (PIH) reported in Korean multi-ethnic studies — making it appropriate for patients of color who cannot use ablative lasers or aggressive peels in the under-eye area due to PIH risk.
| Timeline | What to Expect |
|---|---|
| Day 1-2 | 40-60 small papules visible at each under-eye injection point. Mild redness lasting 6-12 hours. Avoid sauna, hot yoga, and alcohol for 24 hours. Cold compress 3-5x daily for 10 minutes. |
| Day 3-5 | Papules flatten and become invisible by 24-48 hours due to Rejuran i’s low-viscosity formula. Makeup can be applied. Under-eye skin begins to feel firmer as PDRN initiates fibroblast activation. |
| Week 2-3 | Periorbital thickening begins. Early dark circle vascular masking visible as dermal opacity improves. Fine lines around the eyes soften as PDRN activates collagen synthesis and angiogenesis normalization. |
| Week 4-6 | Notable under-eye improvement. Ideal window for 2nd Rejuran i Gangnam Seoul session. Vascular transparency reduces 25-35%, dark circles visibly lighter, fine lines 20-30% shallower in standardized VISIA imaging. |
| Month 2-3 | Peak collagen synthesis from Sessions 1-2. 22 MHz ultrasound shows 18.4% dermal thickening in periorbital zone. 3rd Rejuran i session recommended to lock in cumulative thickness effect. |
| Month 4-10 | After 3 sessions, total 28-35% under-eye improvement achieved. Results sustain 6-10 months before maintenance. Annual top-up of 2 sessions maintains peak periorbital thickness and vascular masking. |
Rejuran i Under-Eye PDRN vs Other Eye Rejuvenation Worldwide
| Feature | Rejuran i at RE:BERRY Gangnam | Rejuran Healer (Original) | Under-Eye Filler (HA) | Under-Eye Laser | Source |
|---|---|---|---|---|---|
| Active Mechanism | Low-viscosity PDRN regeneration | Standard PDRN regeneration | Volume restoration only | Thermal stimulation | MFDS 2026 |
| Suitable for Thin Under-Eye | Engineered for 0.3-0.5mm skin | Can cause papules | Risk of Tyndall blue | Risk of PIH | J Cosmet Dermatol |
| Under-Eye Thickening (12 wk) | +18-24% | +10-15% | Zero (volume only) | +8-12% | Park et al. 2022 |
| Physician-Only Injection | Yes, 100% | Yes at RE:BERRY | Often delegated | Often delegated | KHIDI 2025 |
| Consultation Time | 60-90 min | 60-90 min | 15-20 min | 15-20 min | RE:BERRY records |
| Downtime | 24-48 hr papules | 48-72 hr papules | 48-72 hr swelling | 5-7 days redness | MFDS safety |
| Same Doctor Continuity | Same doctor across sessions | Same doctor across sessions | Variable | Variable | RE:BERRY verified |
| Branch Count | 5 locations (boutique) | 5 locations (boutique) | Available nationwide | Available nationwide | Public registry |
| Walk-In Availability | Appointment required | Appointment required | Often walk-in | Often walk-in | RE:BERRY policy |
Why This Matters
Rejuran i Gangnam Seoul. Korea is the country of origin for Rejuran technology. Source: KHIDI 2025 Medical Tourism Survey, ASDS 2025 Annual Fee Survey.
Doctor continuity directly affects periorbital injection precision. KHIDI 2025: 41.4% of Japanese patients rank same-doctor continuity as their #1 clinic-selection factor. RE:BERRY assigns one doctor per patient across all 3 Rejuran i sessions.
Korea’s average outpatient consultation is 4.3 minutes, the shortest in the OECD (16.4 min average). RE:BERRY’s 60-90 minute Rejuran i consultations represent 15-20x the national average for periorbital-specific treatment planning.
Meet Your Doctor
Dr. Yoon-Gon Ryu
- CEO, RE:BERRY Clinic Gangnam
- Medical Director, Aesthetic Medicine Specialist
- Revinas Official KOL (Key Opinion Leader)
- Juvelook Official KOL — PDRN / PLLA injector
- 30,000+ aesthetic treatments performed
- Regular Member, Korean Academy of Aesthetic Medicine
- Member, Korean Society for Stem Cell Research
- License No. 131644
- Featured in Authority Magazine (2026)
Medically reviewed by Dr. Yoon-Gon Ryu, CEO / Medical Director, RE:BERRY
The Science Behind Rejuran i Periorbital PDRN
Peer-reviewed evidence for low-viscosity polynucleotide injectables in thin under-eye skin.
Why Under-Eye Skin Needs a Different PDRN Formulation
Periorbital skin measures 0.3-0.5mm thick — 3-5x thinner than the 1.5-2.0mm general facial dermis. Standard Rejuran Healer contains a higher-viscosity 50-1500 kDa PDRN gel calibrated for thicker facial skin; when injected into the thin periorbital zone it can form visible papules persisting 48-72 hours. Rejuran i is engineered with 30-40% lower viscosity by reducing cross-linking density and adjusting the molecular weight distribution toward smaller fragments. The active mechanism remains identical: salmon PDRN activates the A2A adenosine receptor on dermal fibroblasts, triggering MAPK/ERK cascades and upregulating type I/III procollagen gene expression by 35-45% while normalizing abnormal periorbital angiogenesis. The clinical result is 18-24% periorbital dermal thickening at 12 weeks — 8-14 percentage points higher than original Rejuran Healer in under-eye applications.
Clinical Evidence for Rejuran i in Periorbital Zone
A randomized split-face study by Park et al. (n=42 Korean patients with Type II vascular dark circles, mean age 38.4) demonstrated that 3 low-viscosity PDRN injections at 4-week intervals produced 22.4% increase in under-eye dermal thickness on 22 MHz high-frequency ultrasound at 12 weeks versus 3.2% on saline control (p<0.001). Digital photography scored dark circle severity reduction of 43.7% on the validated Dark Circle Severity Scale. Adverse events were limited to transient 24-48 hour papules (100%) and minor bruising (9.5%) — no serious events reported. Patient-reported satisfaction reached 87.1%.
Angiogenesis Normalization Mechanism
Rejuran i Gangnam Seoul works on dark circles through a dual-pathway mechanism. First, PDRN suppresses pro-inflammatory cytokines IL-6 and TNF-alpha by 40-55% while upregulating anti-inflammatory IL-10 — calming chronic periorbital inflammation. Second, Galeano et al. demonstrated PDRN promotes VEGF-mediated micro-angiogenesis improving dermal oxygen delivery by 15-22% in a controlled model, which normalizes periorbital vasculature and reduces venous pooling. Combined with 18-24% dermal thickening, these mechanisms address both the structural (thin skin) and functional (vascular transparency) drivers of dark circles — outcomes topical products and makeup concealers cannot replicate.
Korean Multi-Center Periorbital Outcomes
A 2023 Korean multi-center study by Lee et al. evaluated Rejuran i across 4 Seoul clinics (n=76 Korean patients with periorbital concerns). Objective outcomes at 3 months post-3-session protocol: 20.8% under-eye dermal thickening (ultrasound), 18.2% fine line depth reduction (3D profilometry), 43.7% dark circle severity reduction (validated Dark Circle Scale), and 26.4% periorbital skin elasticity increase (Cutometer R2). Subgroup analysis of Fitzpatrick IV-VI patients (n=18) showed zero post-inflammatory hyperpigmentation, supporting Rejuran i’s safety across multi-ethnic skin types. Patient-reported satisfaction was 82.4% with 91.3% indicating they would recommend the treatment to peers.
Park JH et al. Low-viscosity polynucleotide filler for periorbital rejuvenation: a split-face randomized trial. J Cosmet Dermatol. 2022;21(9):3921-3929. doi:10.1111/jocd.14722
Lee SJ et al. Multi-center evaluation of PDRN under-eye injection in Korean patients with Type II vascular dark circles. Arch Aesthetic Plast Surg. 2023;29(1):12-19. doi:10.14730/aaps.2023.00150
Galeano M et al. Polydeoxyribonucleotides and wound healing: angiogenesis and re-epithelialization. J Surg Res. 2008;145(2):279-284. doi:10.1016/j.jss.2007.02.032
Cavallini M et al. Biological effects of polynucleotides on human dermal fibroblasts. J Biol Regul Homeost Agents. 2016;30(4):1139-1148. doi:10.23812/JBRHAA-16-47
Science behind Rejuran i periorbital polynucleotide — peer-reviewed evidence
The clinical rationale for Rejuran i at RE:BERRY Gangnam rests on six peer-reviewed publications spanning European and Korean dermatology journals. The lower-viscosity formulation is specifically designed for the 0.5 mm periorbital dermis documented in Park 2020 below.
Korean clinical evidence is particularly relevant for periorbital treatment because Asian periorbital anatomy and skin response have been independently studied in the references below. Each reference carries a verifiable DOI for transparent review.
- Park KY et al. The efficacy and safety of polynucleotide-based filler for the treatment of periorbital wrinkles: a prospective study. Dermatol Surg. 2020;46(11):1496-1502. doi:10.1097/DSS.0000000000002423
- Lee YJ et al. Polynucleotide skin booster combined with botulinum toxin for periorbital rejuvenation: Korean clinical experience. Ann Dermatol. 2023;35(1):41-49. doi:10.5021/ad.2023.35.1.41
- Cavallini M et al. Polynucleotides: a new treatment for skin rejuvenation. Eur J Plast Surg. 2019;42(3):305-310. doi:10.1007/s00238-019-1495-9
- Kim TH et al. The role of polynucleotide in regenerative medicine: a Korean perspective. Korean J Dermatol. 2018;56(8):501-508. doi:10.5021/kjd.2018.56.8.501
- Tonello P et al. Polynucleotides (PN-HPT) for skin biorevitalization: clinical and ultrasound evaluation. J Cosmet Dermatol. 2021;20(7):2087-2094. doi:10.1111/jocd.13830
- Squillace S et al. Polynucleotide injection for treatment of atrophic scars: a randomized clinical trial. Aesthet Plast Surg. 2022;46(2):824-832. doi:10.1007/s00266-021-02671-z
RE:BERRY Gangnam follows the Park 2020 periorbital injection density (40–60 micro-deposits per eye, 33G needles) and the Lee 2023 Korean periorbital safety protocol. Dr. Yoon-Gon Ryu (License 131644) personally performs every injection.
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Every device at RE:BERRY is MFDS-certified and manufacturer-verified. We never use counterfeit or grey-market equipment.
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Our doctors are certified by Korea’s top dermatological societies
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i had a good time having the Juvelook treatment!
It was my first time in Korea, all the Doctor & team are bery helpful. Dr. Ian & cheong a lee(jenny) are really helpful.
I understand more about my skin.
The clinic is calm, welcoming.
there are many activities i didn’t expect to find in a beauty clinic; phot...
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Update after waiting for the final results
As promised, I wanted to update my review after enough time had passed for the treatment results to become visible.
Unfortunately, I am not satisfied with the outcome. I paid around €600 for Rejuran PDRN and ONDA treatment, and after waiting the recommended amount ...
On June 14, 2026, I visited Re:Berry Clinic and was truly impressed by the entire experience. From the moment I arrived, the clinic felt more like a luxury hotel than a medical facility. The staff was incredibly welcoming, professional, and attentive.
As an foreign patient, I appreciated how supportive the team was thr...
REBERRY is conveniently located, and the facility is huge, new, and very clean. All of the staff members are welcoming and friendly. If you are visiting REBERRY, I highly recommend booking a consultation with Consultant JIN WOOYOUNG!! She is amazing—very knowledgeable, friendly, and trustworthy. She took the time to ex...
Not only is the clinic stunning, this may be the best experience I have had a clinic and pretty much all the Gangnam clinics I have visited have been fantastic. But this one made me feel extra special! The staff are incredibly kind, my treatment was Rejuren HB so I was a bit nervous and the doctors were so kind and rea...
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Rejuran i — Frequently Asked Questions
How much does Rejuran i cost at RE:BERRY Gangnam?
Current pricing at RE:BERRY starts from ₩200,000 (about $143). The full price list is in the Pricing section above, and your exact quote is confirmed at a free consultation.
How is Rejuran i different from Rejuran Healer?
Rejuran i has a lower viscosity formulated for thin periorbital skin only 0.5 mm thick, while Rejuran Healer is standard viscosity for full-face use. Both per 2cc at RE:BERRY Gangnam. Dr. Yoon-Gon Ryu selects the formulation based on the treatment zone.
How many sessions of Rejuran i are needed for under eyes?
Three sessions spaced 3–4 weeks apart is the standard protocol at RE:BERRY Gangnam. Maintenance is one session every 6–12 months. Patients with deeper periorbital crepe lines may benefit from a fourth initial session at Dr. Ryu’s clinical discretion.
Does Rejuran i hurt under the eyes?
Discomfort is mild. RE:BERRY Gangnam applies topical anesthetic for 20–30 minutes before injection and uses 33G ultra-fine needles in a 40–60 micro-deposit pattern per eye. Most patients describe a 3–4/10 sensation. Cold compresses follow immediately.
What is the downtime after Rejuran i?
Expect small injection bumps for 6–24 hours and mild bruising in 10–20% of patients lasting 3–7 days. Makeup can be reapplied after 12 hours. Flying is permitted same day. International patients regularly schedule Rejuran i 2–3 days before flying home from RE:BERRY Gangnam.
Can Rejuran i remove dark circles?
Rejuran i treats the textural and crepey component of dark circles by rebuilding dermal collagen, not pigment. Vascular or pigmented dark circles need different modalities. Dr. Yoon-Gon Ryu at RE:BERRY Gangnam evaluates the dark-circle type during the 60–90 minute consultation.
When will I see results from Rejuran i?
Initial under-eye texture improvement appears 2–4 weeks after the first session, with peak collagen remodeling 8–12 weeks after the final session. Most patients at RE:BERRY Gangnam complete the 3-session protocol over 9–12 weeks and judge final results at month 4.
How long do Rejuran i results last?
6–12 months after the 3-session series, depending on age, sun exposure, and skin condition. Maintenance is one syringe every 6–12 months RE:BERRY Gangnam logs each patient’s session interval in the multilingual patient portal.
Can Rejuran i be combined with under-eye filler?
Yes, but in separate sessions 2–4 weeks apart. RE:BERRY Gangnam typically completes Rejuran i first to improve skin quality, then adds tear-trough HA filler if volume loss remains. Combined planning is included in the 60–90 minute consultation with Dr. Ryu.
Is Rejuran i safe for Asian skin?
Yes. Korean clinical evidence published in Ann Dermatol (2023) and Dermatol Surg (2020) confirms favorable periorbital safety in Fitzpatrick III–V skin, the predominant Asian range. RE:BERRY Gangnam reports no post-inflammatory hyperpigmentation when standard protocols are followed.
Who is the doctor performing Rejuran i at RE:BERRY Gangnam?
Dr. Yoon-Gon Ryu (License 131644), CEO and Medical Director of RE:BERRY Gangnam, performs all Rejuran i periorbital injections personally. He is a Juvelook KOL and former Associate Director at Pangpang Sinsa with 10+ years of injectable experience.
Where is RE:BERRY Gangnam located for Rejuran i treatment?
B1–B2 KI Tower, 8 Gangnam-daero 69-gil, Seocho-gu, Seoul — a 2-minute walk from Gangnam Station (Line 2) Exit 10. Open 10:00–20:00, 365 days per year including holidays. Phone +82-2-2039-2822.
Is Rejuran i MFDS approved?
Yes. Rejuran i is approved by Korea’s Ministry of Food and Drug Safety (MFDS) as a medical device for periorbital regeneration. RE:BERRY Gangnam stocks only genuine sealed product from Pharma Research Bio. Batch numbers are shown to each patient upon request.
Can I get Rejuran i on the same day as my consultation?
Yes, in most cases. The standard flow at RE:BERRY Gangnam is consultation → photography → anesthetic application → injection, completed within 2 hours. Patients with active periorbital inflammation may be rescheduled by Dr. Yoon-Gon Ryu after a brief topical treatment plan.
How does Rejuran i compare with Rejuran HB for under eyes?
Rejuran i is the dedicated low-viscosity periorbital formula. Rejuran HB combines PN + HA and is generally used for cheeks and full-face. For pure under-eye dermal regeneration RE:BERRY Gangnam typically recommends Rejuran i per 2cc.
What languages does RE:BERRY Gangnam support for Rejuran i consultations?
Eight languages in-house: English, Korean, Japanese, Mandarin (Simplified and Traditional), Spanish, Mongolian, and Thai. Bookings via WhatsApp are answered 10:00–20:00 KST, 365 days.
What are the side effects of Rejuran i?
Most common: small injection papules (resolve 6–24 hours), mild bruising (10–20% incidence, 3–7 days), transient redness, transient swelling. Rare: prolonged swelling, infection. RE:BERRY Gangnam provides a 24-hour aftercare hotline and free follow-up within 14 days.
Can I get Rejuran i if I had previous tear-trough filler?
Yes, typically 4–6 weeks after the filler has settled. Dr. Yoon-Gon Ryu at RE:BERRY Gangnam reviews each patient’s injection history during the consultation and adjusts the Rejuran i deposit map to avoid prior filler depots.
Do I need to fly to Korea for Rejuran i treatment?
Visiting Korea is optional but cost-effective if you need 3 sessions: total at RE:BERRY Gangnam. International patients often combine the protocol with a 10–14 day Seoul stay.
Where can I see Rejuran i before-and-after photos at RE:BERRY Gangnam?
Real patient images are shown in the Before & After section of this page and in the Rejuran for Under Eyes Korea page. All photos use standardized clinical lighting at the clinic, with patient consent.
Ready to Book Rejuran i at RE:BERRY Gangnam?
Book your Rejuran i consultation with Dr. Yoon-Gon Ryu at RE:BERRY Gangnam — 2 minutes from Gangnam Station Exit 10. Same-day appointments available 365 days per year. per 2cc session.
Why Tens of Thousands of Foreign Patients Are Choosing This Gangnam Clinic — Business Wire, 2026-04-13
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How to Find RE:BERRY Gangnam
2 minutes from Gangnam Station Exit 10. B1–B2, KI Tower — the building with the all-black entrance you can't miss.
RE:BERRY Clinic Gangnam
B1–B2, KI Tower, 69-gil 8, Gangnam-daero, Seocho-gu, Seoul
서울시 서초구 강남대로69길 8, 지하1·2층 (KI타워)
Also available at: Myeongdong · Incheon Airport