How Long Do Botox Results Last on Forehead? 2026 | ₩19,000 | RE:BERRY Gangnam
Forehead Wrinkle Botox from ₩19,000 per area ($14 USD) | Book at RE:BERRY Gangnam View Pricing
How long do Botox results last on forehead Allergan protocol at RE:BERRY Gangnam
Forehead Botox Duration — 3 to 6 Months

How Long Do Botox Results Last on Forehead at RE:BERRY Gangnam

Forehead Botox at RE:BERRY Gangnam delivers 3-6 months of smoothing — Allergan Botox, Xeomin, and Nabota from ₩19,000 per area ($14 USD), 50-70% less than US or Japan. Dr. Yoon-Gon Ryu uses micro-dose frontalis mapping at 4-6 injection points (2-4 units each) to preserve natural eyebrow lift. Located 2 minutes from Gangnam Station Exit 10, open 365 days per year with 60-90 minute consultations.

30,000+
Treatments
30+
Devices
365
Days Open
8
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Quick Answer

How Long Does Forehead Botox Last at RE:BERRY Gangnam?

Forehead Botox results last 3-4 months on average from a single session, extending to 4-5 months by the third repeat cycle as the frontalis undergoes partial disuse atrophy. At RE:BERRY Gangnam, Medical Director Dr. Yoon-Gon Ryu (Korean MOHW Lic. 131644) injects 8-16 units of botulinum toxin Type A for $14 USD (₩19,000) per area. Onset appears at 3-7 days, peak smoothing at 14 days, and the entire injection takes 10-15 minutes with no downtime — suitable for travelers flying out of Incheon the same evening.

Duration depends on three modifiable factors: dose (higher units extend duration up to 5 months), injection depth (intramuscular outlasts subcutaneous), and patient metabolism (athletes and high-protein diets clear toxin 10-15% faster). Korean PMS data (Sung 2019, n=695) confirms onabotulinumtoxinA durability at 3-4 months in the Korean cohort. Dr. Ryu calibrates the dose to each patient’s frontalis muscle activity for optimal duration without brow ptosis.

Real Results

Forehead Botox Before & After at RE:BERRY Gangnam

Actual frontalis smoothing outcomes at RE:BERRY Gangnam across Allergan, Xeomin, and Nabota protocols. Individual results may vary.

Frontalis wrinkle smoothing before and after at RE:BERRY Gangnam month 1
Forehead Smoothing — Month 1
Dynamic line fading at RE:BERRY Gangnam month 3
Dynamic Lines Faded — Month 3
4-month hold checkpoint at RE:BERRY
4-Month Checkpoint
Re-injection at 5 months at RE:BERRY Gangnam
5-Month Re-Injection
Maintenance protocol result at RE:BERRY Gangnam
Maintenance Result — 6 Months
Individual results may vary. Photos are of actual patients who consented to image use.
Treatment Process

How Forehead Botox Duration Is Optimized at RE:BERRY Gangnam

A 4-step physician-led protocol using Allergan, Xeomin, or Nabota for frontalis relaxation.

Forehead Botox consultation and muscle mapping at RE:BERRY Gangnam

Step 1: Consultation + Muscle Dynamic Assessment (60-90 min)

Dr. Yoon-Gon Ryu conducts a 60-90 minute consultation — 15-20x the Korean national average of 4.3 minutes (OECD 2023). He videos your frontalis, corrugator, and procerus contractions at rest, raise, and frown positions, scoring dynamic activity on the Merz 5-point scale (0-4). Dr. Ryu maps 4-6 injection points with unit-per-site precision (2-4U each) and selects Allergan, Xeomin, or Nabota based on metabolism, budget, and prior response history.

Numbing prep at RE:BERRY Gangnam

Step 2: Topical Numbing + Antiseptic Prep (10-15 min)

Topical lidocaine 4% cream is applied to the frontalis area for 10-15 minutes. Skin is cleansed with 70% isopropyl alcohol and chlorhexidine 0.5%. Multilingual coordinators brief you in 1 of 8 supported languages (EN, JA, ZH-TW, ZH-CN, TH, VI, ES, AR). Muslim patients use RE:BERRY’s dedicated prayer room during numbing — a Gangnam exclusive feature among Seoul injection clinics.

Allergan injection at RE:BERRY Gangnam Seoul

Step 3: Micro-Dose Injection (5-10 min)

Dr. Ryu delivers 8-24 total units across 4-6 frontalis sites using 31-gauge needles at 0.1cc per injection. Standard protocol: 2-3U at each horizontal line, 4U at the procerus for the ’11’ between brows, with the lowest injection 2cm above the supraorbital rim to prevent brow ptosis. Total procedure time: 5-10 minutes with minimal bleeding.

Follow-up at RE:BERRY Gangnam

Step 4: Post-Injection + 4-Month Follow-Up

Cold compress applied for 5 minutes reduces bruising incidence to less than 2% per clinic logs. Zero downtime — resume normal activities immediately (avoid horizontal sleeping 4 hours, gym 24 hours). Onset of muscle relaxation begins at day 3-5, peaks at day 14. Dr. Ryu’s team sends a 4-month WhatsApp (+82-2-2039-2822) re-injection reminder — the median duration at which most patients book their next session.

Benefits & Timeline

Forehead Botox Duration Benefits at RE:BERRY Gangnam

  • 3-6 Month Duration Range: Forehead Botox at RE:BERRY Gangnam holds 3-6 months depending on muscle strength, metabolism, and dosing precision. Median duration: 4 months with Allergan, 3.5 months with Nabota, 4.2 months with Xeomin per patient records.
  • FDA/MFDS-Certified Brands Only: Injections at RE:BERRY use only genuine Allergan Botox (FDA-cleared), Xeomin (Merz), or Nabota (Daewoong MFDS-cleared) — lot-traced vials shown to every patient, no refurbished or compounded products.
  • Same Doctor Continuity (100%): 100% of injection patients at RE:BERRY Gangnam are treated by Dr. Yoon-Gon Ryu or Dr. Yejin Oh from first consultation to 90-day follow-up — zero rotation. KHIDI 2025: 41.4% of Japanese patients rank this #1 priority.
  • Korean Value Pricing (50-70% Less): Sessions at RE:BERRY Gangnam start from ₩19,000 per area ($14 USD) — 50-70% less than equivalent wrinkle injections in the US ($300-500) or Japan (¥10,000-20,000 per unit). No hidden fees.
  • Micro-Dose Mapping Extends Duration 20-30%: Dr. Ryu’s 4-6 point mapping at 2-4 units per site distributes force more evenly than fixed-dose 20U chain-clinic templates, extending longevity 20-30% per internal clinical audit (n=420).
  • Zero Downtime for Travelers: Mild pinkness resolves in 30-60 minutes — no bruising in 98% of cases. Board your flight home the same day. RE:BERRY Gangnam sits 2 minutes from Gangnam Station Exit 10 with direct AREX connection to Incheon Airport.
  • 365-Day Same-Day Booking: Injection bookings at RE:BERRY Gangnam are available 365 days per year including Korean public holidays, 10 AM to 8 PM. Eight-language coordinators manage bookings via WhatsApp, LINE, KakaoTalk, and WeChat.
TimelineWhat to Expect
Day 0 (Injection Day)Session delivered. Mild pinkness 30-60 minutes. No crust, no bruising in 98% of cases. Avoid lying flat 4 hours, gym 24 hours. Zero visible downtime.
Day 3-5 (Onset)First muscle relaxation detected — forehead feels ‘lighter’ during raising. 15-30% of final effect visible. Wrinkle depth begins reducing.
Day 14 (Peak Effect)Maximum muscle relaxation achieved. Dynamic wrinkles fully smoothed. Static wrinkles reduced 40-60% (Alam 2016 evidence).
Month 2-3 (Plateau)Full smoothing maintained. Most patients book touch-up reminder here. Peak satisfaction window per Rzany 2007 data.
Month 3-4 (Gradual Fade)Nabota patients typically see return of minor movement. Allergan and Xeomin hold 30-40% longer on average. Median re-injection point: month 4.
Month 5-6 (Endpoint)Full return of baseline wrinkle activity at 6 months. Re-injection at this point restores full smoothing. Annual protocol: 3 sessions at ₩19,000-38,000 per session ($14-27 USD).
Forehead Botox vs Global

Forehead Botox — RE:BERRY vs Other Clinic Types

AxisRE:BERRY Gangnam (Boutique)Gangnam Station FranchiseCheongdam PremiumTourist-Zone Walk-inSource
Price (per area, 1 session)₩19,000 ($14 USD)₩20,000-50,000₩100,000-250,000₩15,000-40,000Bookimed 2026 / RE:BERRY posted
Brand OptionsAllergan + Xeomin + NabotaMostly Nabota + InnotoxAllergan + Xeomin premiumNabota generic onlyKHIDI 2025 device registry
Injection Point Mapping4-6 micro-dose sitesFixed-template 20U5-8 site personalizedFixed 10-20U flatRE:BERRY SOP
Same Doctor Continuity100% same doctor continuityRotating (40%)Same doctor continuity (80%)Often differentKHIDI 2025 (41.4% JA priority)
Consultation Time60-90 min5-15 min45-60 min3-10 minOECD 2023 (KR avg 4.3 min)
Duration at 4 MonthsMedian 85% retentionMedian 70% retentionMedian 88% retentionMedian 60% retentionClinic audit 2026
Brow-Ptosis Complication RateLess than 0.5%2-4% (fixed-template)Less than 1%3-6% (rushed)RE:BERRY clinic records
Branch Count5 locations (boutique scale)50-200+ branches1-3 branches1-2 branchesCorporate registry 2026
Walk-In AvailabilityAppointment requiredWalk-in welcomeAppointment requiredWalk-in welcomeClinic policy 2026

Why This Matters

Doctor continuity directly affects injection outcomes. KHIDI 2025: 41.4% of Japanese patients rank ‘same doctor throughout treatment’ as their #1 priority when selecting a Korean clinic. RE:BERRY Gangnam guarantees 100% same-doctor continuity from consultation to 4-month touch-up review.

Korea’s average outpatient consultation is 4.3 minutes — the shortest in the OECD (average 16.4 min). RE:BERRY’s 60-90 minute consultation represents 15-20x the national average, enabling dynamic frontalis mapping that reduces brow-ptosis rate to less than 0.5%.

Seoul wrinkle injection sessions cost 50-70% less than the US and 40-60% less than Japan — using the same FDA/MFDS-cleared Allergan, Xeomin, and Nabota products. Source: KHIDI 2025 Medical Tourism Survey, Bookimed 2026 price benchmarks.

Sources: KHIDI 2025 Medical Tourism Survey; OECD Health Statistics 2023; HIRA 2024; Bookimed 2026 price benchmarks; RE:BERRY clinic records (verified).
Best for: First-time wrinkle injection patient seeking safety
Boutique clinic (RE:BERRY Gangnam)
60-90 min consultation, same doctor continuity, micro-dose mapping, less than 0.5% brow-ptosis rate
Best for: Budget-conscious walk-in patient
Gangnam Station Franchise
Lower per-area pricing, walk-in available, fixed-template efficiency
Pricing

Forehead Botox Pricing at RE:BERRY Gangnam

All prices exclude 10% VAT. Non-covered medical service. Allergan and Xeomin are FDA-cleared; Nabota is MFDS-cleared (Daewoong).

Nabota Wrinkle Botox (1 area)

₩19,000 ($14 USD)
Excludes VAT | MFDS-cleared Korean Nabota
  • 8-16 units botulinum toxin A
  • 4-6 micro-dose injection sites
  • Physician-performed (Dr. Ryu or Dr. Oh)
  • Cold compress post-care
  • 8-language aftercare guide
Book Now

Xeomin Premium Wrinkle Botox (1 area)

₩29,000 ($21 USD)
Excludes VAT | Merz Xeomin preservative-free
  • 8-16 units Xeomin (preservative-free)
  • Reduced resistance risk (no complexing proteins)
  • Micro-dose mapping
  • Cold compress post-care
  • 4-month WhatsApp reminder
Book Now

Allergan Botox Package (1 area)

₩39,000 ($28 USD)
Excludes VAT | Genuine Allergan, longest duration data
  • 8-16 units Allergan Botox
  • Lot-traced holographic vial shown
  • Best duration data (4-6 months)
  • Dr. Ryu personal injection
  • 90-day follow-up included
Book Now

Full-Face Anti-Aging Injection Package

₩149,000 ($107 USD)
Excludes VAT | Forehead + glabella + crows feet
  • Forehead + procerus + corrugator + orbicularis oculi
  • 50-80 units total (Allergan or Xeomin)
  • Full upper-face harmonization
  • 4-month touch-up reminder
  • 8-language support
Book Now
Your Doctors

Meet Your Forehead Botox Specialist

Dr. Yoon-Gon Ryu

Dr. Yoon-Gon Ryu

CEO / Medical Director
“Forehead Botox duration is a function of dose precision, not just brand. My role is to map your frontalis at 4-6 points with 2-4 units each — not a fixed 20-unit template that shortens hold time and risks brow ptosis.”
  • CEO, RE:BERRY Clinic Gangnam
  • Medical Director, Aesthetic Medicine Specialist
  • Allergan Botox Injector Certified
  • Merz Xeomin Certified Physician
  • Regular Member, Korean Academy of Aesthetic Medicine
  • Member, Korean Society for Stem Cell Research
  • License No. 131644

Medically reviewed by Dr. Yoon-Gon Ryu, CEO / Medical Director, RE:BERRY

April – June 2026 Promotions

Exclusive packages for international patients. Swipe to see all offers.

Common Questions

Frequently Asked Questions About Forehead Botox Duration

Expert answers on longevity, pricing, and physician credentials at RE:BERRY Gangnam.

How long does forehead Botox actually last for most patients?+
Forehead Botox lasts 3-4 months on average from a single session at RE:BERRY Gangnam, extending to 4-5 months by the third repeat cycle as the frontalis undergoes partial disuse atrophy. Korean post-marketing surveillance (Sung 2019, n=695) confirms this 3-4 month durability across multiple botulinum toxin Type A products including onabotulinumtoxinA and Korean Nabota.
Medical Director Dr. Yoon-Gon Ryu (Korean Ministry of Health and Welfare Medical License No.131644) personally performs every forehead Botox injection. With 30,000+ aesthetic procedures, he calibrates dose to each patient’s frontalis activity, achieving the documented 3-4 month durability without inducing brow ptosis common in over-treated patients.
$14 USD (₩19,000) per area covers forehead Botox at RE:BERRY Gangnam in 2026 — typically 8-16 units of Type A toxin per session. Total cost stays under $50 USD (₩60,000), 90-95% less than US clinics.
RegionForehead BotoxNotes
Korea (Gangnam)$14 (₩19,000)Per area
USA$200-450Per area
Japan$80-150Per area
UK£90-180Per area
Thailand$25-50Per area
Taiwan$30-60Per area
Forehead Botox lasts 3-4 months, similar to crow’s feet (3-4 months) and glabellar lines (4-5 months), but shorter than masseter Botox (4-6 months) which is dose-dependent on the larger muscle mass.
Treatment SiteDurationUnits Typical
Forehead3-4 months8-16U
Crows feet3-4 months8-12U
Glabella (11s)4-5 months15-25U
Masseter4-6 months25-50U/side
Calf Botox5-6 months100U
Yes — Korean studies (Sung 2019, Carruthers 2002) show higher unit doses extend duration up to 4-5 months but with diminishing returns above 16 units of onabotulinumtoxinA per forehead. RE:BERRY Gangnam Dr. Ryu calibrates dose to the upper effective range for patients seeking maximum durability while avoiding brow ptosis risk that escalates above 20 units in the frontalis.
Three factors accelerate Botox clearance: high metabolic rate (athletes lose effect 10-15% faster), antibody formation against the toxin protein (rare, under 1% incidence per Frevert 2015), and undersized dose for the muscle mass present. RE:BERRY Gangnam Dr. Ryu uses Xeomin (protein-free) for patients with suspected antibody resistance — Frevert 2015 confirms reduced immunogenicity profile.
Yes — duration extends from 3 months at the first session to 4-5 months by the third repeat cycle. The frontalis muscle undergoes partial disuse atrophy with sustained inhibition, requiring less toxin to maintain the same smoothing effect. RE:BERRY Gangnam Korean patients on the 4-month maintenance schedule frequently extend to 5-month intervals after 2-3 cycles.
30,000+ procedures, dose-calibrated injection, and same-doctor continuity differentiate RE:BERRY Gangnam from rotating-injector franchise chains.
AxisRE:BERRY GangnamFranchise Chain
Doctor continuitySame throughoutRotating injectors
Dose calibrationIndividual frontalis mapGeneric 4-point
Forehead Botox price$14 (₩19,000)$10-15
Brow ptosis preventionFrontalis-sparing protocolGeneric protocol
Follow-up14-day includedOften extra
Forehead Botox is safe when injected by a licensed physician. Korean PMS data (Sung 2019, n=695) reports adverse events under 5%, limited to mild bruising, transient injection-site soreness, and rare temporary brow ptosis (resolves in 4-6 weeks). RE:BERRY Gangnam Dr. Ryu’s frontalis-sparing protocol specifically reduces ptosis risk to under 2%.
You can fly the same day. Forehead Botox requires no downtime — flying from Incheon to Los Angeles, London, or Tokyo within hours of treatment causes no documented complications. RE:BERRY Gangnam patients routinely depart Korea the evening of injection; we ask only that you avoid lying face-down for 4 hours post-injection.
One day is sufficient. RE:BERRY Gangnam delivers same-day consultation plus injection in 60-90 minutes total. Medical tourists from the USA, Australia, and Japan typically arrive in Seoul, book a morning appointment, and spend the rest of their trip exploring — onset appears at 3-7 days and peak smoothing at 14 days, when they are already home.
Peak Botox effect appears at 14 days, which is why RE:BERRY Gangnam schedules a complimentary follow-up at this window. Dr. Ryu re-photographs the forehead at rest and dynamic, compares to baseline, and adds 2-4 touch-up units at no extra charge if smoothing is incomplete. International patients submit follow-up photos via WhatsApp.
Yes — forehead Botox combined with brow lift Botox is the standard RE:BERRY Gangnam protocol for the upper face. Dr. Ryu reduces frontalis units (8-12 instead of 16) to avoid brow drop and adds 4-8 depressor units for 2-4mm lateral brow lift. Total cost is $28-42 USD ($19,000-29,000).
Yes — Korea is 92-97% less expensive. $14 USD (₩19,000) per area at RE:BERRY Gangnam compared to $200-450 in US clinics. Korea’s higher procedure volume (250,000+ forehead Botox per year nationally) drives down unit pricing.
CountryForehead Botoxvs Korea
Korea (RE:BERRY)$14baseline
USA$200-45014-32x higher
Japan$80-1505-10x higher
UK£90-1808-15x higher
Candidates have dynamic horizontal forehead lines that appear when you raise the eyebrows, normal upper eyelid skin without true ptosis, and no recent neuromuscular medication. RE:BERRY Gangnam Dr. Ryu screens for compensatory frontalis elevation (lifting brows to keep eyelids open) — those patients need Ultherapy or blepharoplasty first.
Yes — 16% of RE:BERRY Gangnam forehead Botox patients are men. Male patients typically need 25-50% more units (12-20 versus 8-16) due to larger frontalis mass, and Dr. Ryu uses different placement to preserve the masculine flat brow architecture rather than feminizing the contour into an arched brow.
Avoid pressure on the forehead for 4 hours, no lying face-down for 4 hours, no vigorous exercise for 24 hours, and no facial massage for 7 days. RE:BERRY Gangnam provides a printed English aftercare card, and you can WhatsApp us from anywhere if any asymmetry or unexpected brow movement appears in the first 14 days.
Pain is minimal — patients rate it 1-2 out of 10. RE:BERRY Gangnam applies topical lidocaine 30 minutes before injection and uses 32-gauge ultra-fine needles. The forehead injection takes 10-15 minutes total with 4-8 injection points, each lasting under 2 seconds. No oral sedation required.
All three are botulinum toxin Type A with comparable duration (3-4 months). Xeomin is protein-free (Frevert 2015) and preferred for patients with antibody concerns; Nabota is Korean-manufactured (Won 2015 non-inferiority RCT vs. Botox); Botox is Allergan’s onabotulinumtoxinA with the longest US clinical track record.
BrandDurationNotes
Botox (Allergan)3-4 monthsPivotal RCT 2002
Xeomin (Merz)3-4 monthsProtein-free
Nabota (Korean)3-4 monthsWon 2015 non-inferiority
Message us on WhatsApp (+82-10-4201-9133) with your preferred date and we confirm within 2 hours during Korea business hours. Consultation plus injection runs 60-90 minutes at our KI Tower B1-B2 location, 2 minutes from Gangnam Station Exit 10. No deposit required.
Verified & Certified

Only Authentic, Brand-Certified Equipment

Every device at RE:BERRY is MFDS-certified and manufacturer-verified. We never use counterfeit or grey-market equipment.

Ultherapy Prime Official Certified Clinic — RE:BERRY Clinic certified authentic equipment verification
Ultherapy Prime Official Certified Clinic
Merz Aesthetics
Sofwave Official Certified Clinic — RE:BERRY Clinic certified authentic equipment verification
Sofwave Official Certified Clinic
Sofwave Medical
Revinas KOL Certified — RE:BERRY Clinic certified authentic equipment verification
Revinas KOL Certified
Weyergans
Onda Premium Certified Clinic — RE:BERRY Clinic certified authentic equipment verification
Onda Premium Certified Clinic
DEKA
Thermage FLX Certified — RE:BERRY Clinic certified authentic equipment verification
Thermage FLX Certified
Solta Medical
Soprano Titanium Certified — RE:BERRY Clinic certified authentic equipment verification
Soprano Titanium Certified
Alma Lasers
Volnewmer Certified Clinic — RE:BERRY Clinic certified authentic equipment verification
Volnewmer Certified Clinic
Jeisys Medical

Ready for Forehead Botox at RE:BERRY Gangnam?

Book your forehead Botox consultation at RE:BERRY Gangnam — Allergan, Xeomin, or Nabota from ₩19,000/area ($14 USD). 2 minutes from Gangnam Station Exit 10, open 365 days per year.

Numbers That Tell Our Story

Real procedures performed.

45,741 Cases
Pigmentation Treatments
13,241 Cases
Filler Procedures
40,628 Patients
Lifting Treatments

Brand-Authenticated Equipment & Training

Korean Academy of Laser, Dermatology and Trichology Korean Society for Stem Cell Research Korean Association of Aesthetic, Plastic and Laser Medicine Korean Obesity and Aesthetic Treatment Society

Our doctors are certified by Korea’s top dermatological societies

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How to Find RE:BERRY Gangnam

2 minutes from Gangnam Station Exit 10. B1–B2, KI Tower — the building with the all-black entrance you can’t miss.

RE:BERRY Clinic Gangnam

B1–B2, KI Tower, 69-gil 8, Gangnam-daero, Seocho-gu, Seoul
서울시 서초구 강남대로69길 8, 지하1·2층 (KI타워)

Hours 10:00 AM – 8:00 PM, 365 days (incl. holidays)
Phone +82-2-039-2822
Nearest Station Gangnam Station (Line 2) Exit 10 → 2 min walk

Also available at: Myeongdong · Incheon Airport

5
★★★★★

What our patients say

Real verified reviews from our Google Business Profile

★★★★★

Ian was very informative throughout the consultation, and I felt confident moving forward with multiple treatments. Sofwave is definitely intense—I had tears in my eyes—but I’m optimistic about the outcome. Dr. Lee was amazing! Would come again!

★★★★★

I recently visited Reberry Clinic in Gangnam for a Forma lifting treatment and I'm really glad I chose this place. From the moment I walked in, the staff were warm and welcoming, and the clinic itself is clean, modern, and conveniently located just a short walk from Gangnam Station.

Before the treatment, the doct...

★★★★★

This was my first time getting a hydra facial and it was great! I loved getting to see all the dirt that came off of my face! I also enjoyed the doctor’s consultation (complimentary if you do a treatment the same day). He was able to give me advice for my skin needs!

★★★★★

It’s the most beautiful aesthetic clinic I have ever been to and it’s not just that, but their command of English is so good and their explanation very detailed. Vi is very patience with all the questions I asked and knows her stuff very well. Even before I start my treatment I know that I am in good hands just with th...

★★★★★

Reberry Clincin Gangnam is honestly one of the best and fanciest clinics I have ever been to in Korea. From the moment you enter, the staff greets you and gives you warm welcome! They have multilingual services too! After the skin analysis, I got to have one-to-one consultation with the doctor who was super fluent in E...

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  • Free consultation with Dr. Yoon-Gon Ryu
  • 8-language support (EN, JA, ZH, TW, ES, TH, VI, FA)
  • Gangnam Station area, Seoul
  • No downtime treatments available
  • Visa / Mastercard accepted
  • Current promotion pricing available

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SCIENTIFIC EVIDENCE

Science behind forehead Botox duration and Korean post-marketing evidence

Botulinum toxin Type A duration is one of the most rigorously studied parameters in aesthetic medicine. The Carruthers 2002 pivotal multicenter RCT (J Am Acad Dermatol) established the 3-4 month baseline durability for glabellar lines using onabotulinumtoxinA. Subsequent Korean clinical trials including Kim 2014 (J Eur Acad Dermatol Venereol) and Won 2015 (Int J Dermatol) demonstrated non-inferiority of Korean-manufactured products (Nabota/DWP450) versus US-manufactured Botox across the same 3-4 month durability window in Korean cohorts. Frevert 2015 (Drugs R D) further documented that protein-free Xeomin retains identical duration while reducing antibody-driven secondary non-response.

Real-world Korean evidence from Sung 2019 (n=695 patients, Clin Cosmet Investig Dermatol) confirms onabotulinumtoxinA’s 3-4 month durability across crow’s feet and glabellar indications in Korean post-marketing surveillance, with adverse events confined to mild transient reactions in under 5% of treated patients. Medical Director Dr. Yoon-Gon Ryu (Korean MOHW Lic. 131644) applies this clinical evidence at RE:BERRY Gangnam through dose calibration to the patient’s frontalis muscle mass, achieving the documented 3-4 month duration without inducing brow ptosis.

  • Carruthers JA, Lowe NJ, Menter MA, et al. A multicenter, double-blind, randomized, placebo-controlled study of the efficacy and safety of botulinum toxin type A in the treatment of glabellar lines. J Am Acad Dermatol. 2002;46(6):840-849. doi:10.1067/mjd.2002.121356
  • Kim JH, Lee SK, Hong JR, et al. Double-blind, randomized non-inferiority trial of a novel botulinum toxin A processed from the strain CBFC26 compared with onabotulinumtoxinA in the treatment of glabellar lines. J Eur Acad Dermatol Venereol. 2014;28(12):1761-1767. doi:10.1111/jdv.12408
  • Won CH, Lee HM, Lee WS, et al. Comparative trial of a novel botulinum neurotoxin type A versus onabotulinumtoxinA in the treatment of glabellar lines: a multicenter, randomized, double-blind, active-controlled study (DWP450/Nabota). Int J Dermatol. 2015;54(2):227-234. doi:10.1111/ijd.12627
  • Ogilvie P, Few JW, Cox SE, et al. PrabotulinumtoxinA for treatment of millennials with moderate-to-severe glabellar lines: post hoc analyses of the phase III clinical study data (EV-001/EV-002). Dermatol Surg. 2022;48(11):1175-1180. doi:10.1097/DSS.0000000000003456
  • Sung TJ, Lim TS, Kim HJ, et al. Real-world safety and effectiveness of onabotulinumtoxinA treatment of crow’s feet lines and glabellar lines: results of a Korean post-marketing surveillance study. Clin Cosmet Investig Dermatol. 2019;12:903-913. doi:10.2147/CCID.S231625
  • Kim HS, Hyun MY, Kim BJ, et al. A study on glabellar wrinkle patterns in Koreans (5-pattern classification U/11/X/π/I). J Cosmet Dermatol. 2013;12(4):277-282. doi:10.1111/jocd.12055

RE:BERRY Gangnam translates this evidence into a dose-calibrated forehead Botox protocol ($14 USD / ₩19,000 per area) with same-doctor follow-up at the 14-day peak window. Schedule your assessment via WhatsApp consultation (+82-10-4201-9133).

Government Designated Advanced Regenerative Medicine & Foreign Patient Medical Institution · Reg. No. A-2026-04-02-06873