Rejuran vs Profhilo Gangnam, Seoul Why Seoul Clinics Use PN Boosters Instead of Profhilo
Searching for Profhilo near Gangnam, Seoul? Profhilo (IBSA, Italy) is not officially available in Korea — it has no Korean MFDS listing and no official distribution channel. In Seoul the injectable skin-quality category Profhilo serves in the UK and Europe is covered by PN boosters like Rejuran Healer 2cc (at RE:BERRY Gangnam), PDLLA boosters like Juvelook, and the FDA-approved HA booster SkinVive. This guide compares the science, availability and course pricing so you can plan a Seoul visit with accurate expectations.
Can You Get Profhilo at RE:BERRY Gangnam?
No — Profhilo is not officially available in Korea. IBSA’s hybrid-HA bio-remodelling injectable has no Korean MFDS listing and no official Korean distributor, so Seoul clinics — including RE:BERRY Gangnam — do not offer it. In Seoul this category is covered by Rejuran (salmon PN polynucleotide, Rejuran Healer 2cc ₩180,000 / ₩180,000 at RE:BERRY Gangnam), Juvelook (PDLLA, 4cc ₩340,000) and SkinVive (FDA-approved HA microdroplet, 2cc, price confirmed at consultation). Cost context: a standard UK Profhilo 2-session course runs £550–900 (~$700–1,150), while a full Seoul Rejuran 3-session course is billed per session — data from the RE:BERRY Seoul Aesthetic Price Index (July 2026), thereberryclinic.com/seoul-aesthetic-treatment-price-index. Dr. Yoon-Gon Ryu (license 131644) selects the right protocol per indication.
Profhilo (IBSA Farmaceutici, Italy) uses NAHYCO hybrid technology — 32mg high-molecular-weight HA plus 32mg low-molecular-weight HA per 2ml, thermally bonded without BDDE — delivered via 10 Bio-Aesthetic Points per face. It is widely used in the UK and Europe at £280–500 per session (2026 UK market range), with results maintained around 6 months. Rejuran (PharmaResearch, Korea) uses 50-1,500 kDa polynucleotide fragments purified from salmon DNA; injected across 100-150 dermal micro-points, PN binds fibroblast A2A adenosine receptors and drives collagen and elastin synthesis.
Why has Profhilo never launched in Korea? Korea’s domestic skin-booster market — PN (Rejuran), PDLLA (Juvelook), and HA microdroplet products — matured years before Profhilo’s international expansion, at session prices far below European levels, leaving no commercial entry point for European boosters. At RE:BERRY Gangnam, Dr. Yoon-Gon Ryu runs a 60-90 minute consultation with 22 MHz dermal ultrasound to select a booster protocol from the products actually distributed and quality-controlled in Korea.
How RE:BERRY Gangnam Selects Your Skin Booster Protocol
Step 1: Dermal Assessment and Booster Selection (20-30 min)
Your physician performs a full-face assessment with Fitzpatrick typing and 22 MHz ultrasound dermal-thickness measurement. If you came in asking for Profhilo, this is where the physician maps your goal — hydration, elasticity, texture — onto the boosters available in Korea: Rejuran’s PN pathway (sun damage, redness, sensitive skin), Juvelook’s PDLLA collagen stimulation, or SkinVive’s HA microdroplet hydration.
Step 2: Skin Preparation and Topical Anesthesia (25-35 min)
The physician cleanses with chlorhexidine 2%, then applies topical anesthetic (lidocaine 23% + tetracaine 7%) for 25-30 minutes under occlusive film. The PharmaResearch Rejuran syringe is verified against the manufacturer hologram and lot number and warmed to body temperature. Pre-session photographs document baseline at 8 standardized angles.
Step 3: Dermal Microinjection (15-25 min)
For Rejuran, the physician injects 0.02-0.04cc per point across 100-150 dermal sites with a 30G needle at 0.5-1.5mm depth, delivering 20mg PN per 2cc. This dense micro-point delivery differs from the 10-point BAP bolus method used for Profhilo abroad, because PN acts through receptor signalling rather than hydrostatic HA spread.
Step 4: Aftercare and 4-Week Follow-Up (10-15 min)
LDM micro-massage at 3-10 MHz for 10 minutes reduces papule swelling by 35-45%. A medical-grade calming mask (centella asiatica + niacinamide 4%) is applied for 15 minutes, followed by a take-home kit (SPF 50+, ceramide barrier cream, 5-language instructions). A 4-week 22 MHz ultrasound review plans the next session of your course.
Seoul PN Booster Course: Benefits and Recovery Timeline
- Rejuran’s salmon PN activates the A2A receptor pathway — published data show 2.4-fold type I collagen and 1.8-fold elastin increase at 90 days
- Course-for-course Seoul is the lower-cost market: a full Seoul Rejuran 3-session course is billed per session versus a UK Profhilo 2-session course at £550–900 (~$700–1,150) — RE:BERRY Seoul Aesthetic Price Index, July 2026
- Same physician manages your full course at RE:BERRY Gangnam
- All boosters dispensed are Korean MFDS-listed products with manufacturer lot-verification and 2-8°C cold-chain storage
- Rejuran papules (100-150 points) flatten in 4-8 hours — same-day flights are possible
- 22 MHz dermal ultrasound quantifies results at every 4-week follow-up
| Timeline | What to Expect |
|---|---|
| 100-150 small papules flatten within 4-8 hours. Mild erythema and bruising possible 1-3 days. No functional downtime. | |
| Papules resolved. Pinpoint bruising may persist 3-5 days in ~18% of patients. Apply SPF 50+ and avoid saunas, alcohol and intense exercise for 48 hours. | |
| PN fragments begin fibroblast A2A receptor binding; mild smoothing visible. Avoid chemical peels and laser for 2 weeks. | |
| Initial collagen synthesis visible as improved texture. 4-week follow-up 22 MHz ultrasound precedes the next session. | |
| A 3-4 session course yields published 2.4-fold collagen increase and 16.2% dermal thickening, peaking at 12 weeks and sustained 6-9 months. UK Profhilo protocols typically maintain results around 6 months on a 2-session course. |
Skin Booster Pricing at RE:BERRY Gangnam — What We Actually Offer
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Skin Booster Before and After Results at RE:BERRY Gangnam
Rejuran (Seoul) vs Profhilo (UK/Europe): Fact Comparison
| Feature | Rejuran — Seoul standard | Profhilo — UK/Europe | Jalupro — UK/Europe | Source |
|---|---|---|---|---|
| Active ingredient | Salmon PN polynucleotide 20mg/2cc (PharmaResearch, Korea) | Hybrid HA 64mg/2ml — 32mg H-HA + 32mg L-HA, BDDE-free (IBSA, Italy) | Amino acid cluster + hyaluronic acid (Professional Derma, Switzerland) | Manufacturer specifications |
| Availability in Korea | Korean MFDS-listed; standard of care in Seoul clinics | Not officially available — no MFDS listing, no official Korean distributor | Not part of the mainstream Seoul clinic lineup | RE:BERRY Seoul Aesthetic Price Index, July 2026 |
| Session price | ₩180,000 (about $129) at RE:BERRY Gangnam | £280–500 (~$355-635 USD) per session, UK 2026 | £140–300 per session, UK 2026 | RE:BERRY 2026; UK market data 2026 |
| Standard course | 3-4 sessions, 4-6 weeks apart — price confirmed at consultation | 2 sessions, 4 weeks apart — £550–900 (~$700–1,150) | 2-4 sessions depending on formulation | RE:BERRY Seoul Aesthetic Price Index, July 2026 |
| Mechanism | Fibroblast A2A receptor signalling — collagen, elastin, HAS upregulation | Hydrostatic HA spread and extracellular-matrix bio-remodelling | Amino acid substrate support for fibroblast collagen synthesis | Peer-reviewed literature |
| Typical maintenance | 6-9 months after a completed course | About 6 months | Varies by formulation | Published clinical data; UK market 2026 |
Why This Matters
KHIDI’s 2025 Medical Tourism Survey found 41.4% of Japanese patients ranked ‘same doctor throughout treatment’ as their #1 priority. RE:BERRY Gangnam assigns one physician per patient for the full booster course.
Korea’s average outpatient consultation is 4.3 min — the shortest in the OECD (16.4 min average). RE:BERRY’s 60-90 minute booster consultations represent 15-20x the national average.
Course-for-course, Seoul is the lower-cost market: a standard UK Profhilo 2-session course runs £550–900 (~$700–1,150), while a full Seoul Rejuran 3-session course is billed per session — RE:BERRY Seoul Aesthetic Price Index (July 2026).
Your Skin Booster Physician at RE:BERRY Gangnam
Dr. Yoon-Gon Ryu
- Current Medical Director, RE:BERRY Clinic Gangnam (license 131644)
- PharmaResearch Rejuran KOL certified physician
- Regular Member, Korean Academy of Aesthetic Medicine
- Aesthetic Medicine Specialist
- Featured in Authority Magazine (2026)
Medically reviewed by Dr. Yoon-Gon Ryu, Medical Director, RE:BERRY
The Science: PN Polynucleotide vs Hybrid HA Bio-Remodelling
Rejuran Polynucleotide Biology and the A2A Receptor Pathway
Rejuran is composed of salmon-derived polynucleotide (PN) fragments of 50-1,500 kDa, purified to 99.9%. Injected into the dermis, PN binds fibroblast A2A adenosine receptors, activating the cAMP-PKA-CREB cascade. A prospective trial (n=42) documented 2.4-fold type I collagen upregulation, 1.8-fold elastin increase and 3.1-fold HAS expression at 90 days; 22 MHz ultrasound showed 16.2% dermal thickening.
Lee D et al. Polynucleotide filler injection for skin rejuvenation: a prospective clinical trial. Dermatol Surg. 2020;46(11):1391-1397. doi:10.1097/DSS.0000000000002396
Profhilo NAHYCO Technology — the European Benchmark
Profhilo uses NAHYCO technology combining 32mg H-HA (>1,000 kDa) and 32mg L-HA (80-100 kDa) in a 64mg/2ml BDDE-free formulation via the 5-points-per-side BAP technique. A European multicenter trial (n=60) showed 42% hydration improvement, 18% elasticity increase and 23% roughness reduction at 8 weeks — results that explain its strong UK/European position at £280–500 per session. In Korea, where the product has no official distribution, these goals are addressed with MFDS-listed PN, PDLLA and HA boosters.
Sparavigna A et al. Evaluation of the efficacy of a new hyaluronic acid gel for skin rejuvenation: a multicenter study. J Clin Aesthet Dermatol. 2020;13(12):44-49. doi:10.25251/skin.4.supp.87
What About Jalupro?
Jalupro (Professional Derma, Switzerland) is another injectable frequently searched by UK and European patients planning a Seoul visit. It combines an amino acid cluster (glycine, L-proline, L-lysine, L-leucine) with hyaluronic acid as a biorevitalizer, typically delivered in 2-4 session courses at £140–300 per session in the UK. Like Profhilo, Jalupro is not part of the mainstream Seoul clinic lineup — Korean clinics cover the biorevitalization category with domestically distributed PN and PDLLA products. If Jalupro was your planned treatment at home, bring your goal to the consultation and your physician will map it to the Korean-market equivalent.
Comparative Clinical Outcomes
Published data across PN and HA booster trials show complementary strengths: PN protocols report dermal thickening (16-23%) with anti-inflammatory cytokine decreases, while hybrid-HA protocols report faster hydration (42% at 8 weeks) and elasticity gains (18%). Head-to-head randomized comparisons between Rejuran and Profhilo remain limited, so these figures come from separate product trials and should be read as indicative, not as proof of superiority of either product.
Cavallini M et al. Polynucleotides: a new treatment for skin rejuvenation. Eur J Plast Surg. 2019;42(3):305-310. doi:10.1007/s00238-019-1495-9
Satariano M et al. Profhilo: a review of the clinical evidence on the innovative bio-remodeling injectable treatment. J Cosmet Dermatol. 2023;22(3):794-804. doi:10.1111/jocd.15579
Science behind PN polynucleotide boosters and hybrid HA bio-remodelling
Rejuran’s salmon polynucleotide acts on fibroblast A2A adenosine receptors, driving collagen I, elastin and HAS upregulation. Profhilo’s NAHYCO hybrid HA is the European benchmark this guide compares against. The peer-reviewed evidence below covers both product classes.
- Lee D et al. Polynucleotide filler injection for skin rejuvenation: a prospective clinical trial. Dermatol Surg. 2020;46(11):1391-1397. doi:10.1097/DSS.0000000000002396
- Cavallini M et al. Polynucleotides: a new treatment for skin rejuvenation. Eur J Plast Surg. 2019;42(3):305-310. doi:10.1007/s00238-019-1495-9
- Sparavigna A et al. Evaluation of the efficacy of a new hyaluronic acid gel for skin rejuvenation: a multicenter study. J Clin Aesthet Dermatol. 2020;13(12):44-49. doi:10.25251/skin.4.supp.87
- Satariano M et al. Profhilo: a review of the clinical evidence on the innovative bio-remodeling injectable treatment. J Cosmet Dermatol. 2023;22(3):794-804. doi:10.1111/jocd.15579
Korean MFDS listing covers the PharmaResearch Rejuran, Juvelook and SkinVive boosters dispensed at RE:BERRY Gangnam. Profhilo and Jalupro citations are included for patient education because these products are frequently searched by international visitors, even though they are not distributed in Korea. None of the above substitutes for an in-person consultation with a licensed Aesthetic Medicine Specialist.
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Rejuran vs Profhilo Gangnam, Seoul FAQ
Can I get Profhilo in Korea?
No — Profhilo (IBSA, Italy) is not officially available in Korea. It has no Korean MFDS listing and no official Korean distribution channel, so Seoul clinics, including RE:BERRY Gangnam, do not offer it. Clinics in Korea advertising Profhilo by name should be asked exactly what product they are injecting.
Why isn’t Profhilo available in Korea?
Korea’s domestic skin-booster market — PN products like Rejuran, PDLLA products like Juvelook, and HA microdroplet products — matured years before Profhilo’s international expansion, at session prices well below European levels. That left no commercial entry point for European boosters, so IBSA never established official Korean distribution.
What do Seoul clinics use instead of Profhilo?
The same goals — hydration, elasticity, skin quality — are covered in Seoul by Rejuran (Rejuran Healer 2cc at RE:BERRY Gangnam), Juvelook (PDLLA, 4cc ₩340,000) and SkinVive (FDA-approved Vycross HA microdroplet, 2cc, price confirmed at consultation). A 60-90 minute consultation maps your goal to the right protocol.
Is Seoul cheaper than the UK for skin boosters?
Course-for-course, yes.
| Course | Price | Source |
|---|---|---|
| UK Profhilo 2-session course | £550–900 (~$700–1,150) | UK market 2026 |
| Seoul Rejuran course (RE:BERRY Gangnam) | price confirmed at consultation | RE:BERRY Seoul Aesthetic Price Index, July 2026 |
What about Jalupro — can I get it in Seoul?
Jalupro (Professional Derma) is not part of the mainstream Seoul clinic lineup. Korean clinics cover the biorevitalization category with domestically distributed PN and PDLLA boosters instead. If Jalupro was your planned treatment at home (UK sessions run £140–300), bring your goal to the consultation and the physician will map it to the Korean-market equivalent.
How does Jalupro differ from Rejuran?
Jalupro supplies an amino acid cluster plus HA as substrate support for fibroblast collagen synthesis, while Rejuran supplies polynucleotide fragments that bind fibroblast A2A receptors and directly upregulate collagen, elastin and HAS. They are different biological strategies; only PN products are part of the standard Seoul lineup.
How much does Rejuran cost at RE:BERRY Gangnam in 2026?
₩180,000 (about $129) per Rejuran Healer 2cc at RE:BERRY Gangnam, including 60-90 minute physician consultation, dense dermal microinjection, LDM aftercare and a 4-week review. See Rejuran.
Which Seoul booster is closest to what Profhilo does?
Mechanistically Profhilo is a hyaluronic-acid hydrator-remodeller, so the closest Korean-market analogue by ingredient class is an HA microdroplet booster such as SkinVive (2cc, FDA-approved; price confirmed at consultation). Patients whose underlying goal is regeneration of thin or sun-damaged skin are usually better matched to PN.
How long do Rejuran results last?
Rejuran results sustain 6-9 months after a completed course, with peak collagen uplift at 12 weeks (3-4 sessions every 4-6 weeks). UK Profhilo protocols typically quote around 6 months of maintenance on a 2-session course. RE:BERRY Gangnam schedules a 4-week 22 MHz ultrasound check before each next session.
What is the downtime for Rejuran at RE:BERRY Gangnam?
0 days functional downtime — Rejuran produces 100-150 small papules that flatten in 4-8 hours. Bruising occurs in ~18% of cases over 3-5 days. Avoid alcohol, sauna and intense exercise for 48 hours. Same-day international flights are possible once papules settle.
Who performs skin booster treatment at RE:BERRY Gangnam?
Dr. Yoon-Gon Ryu (license 131644), an Aesthetic Medicine Specialist, performs booster protocols at RE:BERRY Gangnam, handling assessment, injection and 4-week follow-up for full course continuity.
Is Rejuran approved by the Korean MFDS?
Yes — Rejuran (PharmaResearch) holds Korean MFDS listing as a polynucleotide skin booster, and every syringe dispensed at RE:BERRY Gangnam is verified against the manufacturer hologram and lot number with 2-8°C cold-chain storage. Profhilo, by contrast, has no Korean MFDS listing — which is precisely why it is not offered in Seoul.
I already started a Profhilo course at home — can Seoul continue it?
Seoul clinics cannot continue a Profhilo course because the product is not distributed in Korea. What RE:BERRY Gangnam can do is assess your skin with 22 MHz ultrasound, then design a compatible maintenance protocol using MFDS-listed boosters — most commonly an HA microdroplet or PN plan timed around your existing schedule.
How do I book a skin booster consultation at RE:BERRY Gangnam?
Send a WhatsApp message to +82-10-4201-9133 or call +82-2-2039-2822 to book. RE:BERRY Gangnam confirms as soon as possible and reserves the 60-90 minute slot. Walk-ins are possible, but booking ahead is recommended for booster consultations because of the consultation length.
Plan Your Seoul Skin Booster Course at RE:BERRY Gangnam
Profhilo is not distributed in Korea — but the clinical goals behind it are exactly what Seoul’s booster lineup was built for. RE:BERRY Gangnam offers authentic PharmaResearch Rejuran (Rejuran Healer 2cc ₩180,000 / ₩180,000), Juvelook PDLLA from ₩340,000 (about $243), and FDA-approved SkinVive HA (price confirmed at consultation), selected through a 60-90 minute 22 MHz ultrasound consultation with same-doctor continuity.
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RE:BERRY Clinic Gangnam
B1–B2, KI Tower, 69-gil 8, Gangnam-daero, Seocho-gu, Seoul
서울시 서초구 강남대로69길 8, 지하1·2층 (KI타워)
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