Xeomin Pure Botulinum Toxin for Precision Wrinkle Treatment in Gangnam Seoul
Xeomin (incobotulinumtoxinA) by Merz Aesthetics is the world’s only complexing-protein-free botulinum toxin type A — delivering pure neurotoxin without the accessory proteins found in conventional Botox. This pharmaceutical purity means lower risk of antibody formation and consistent results even with long-term use. At RE:BERRY Gangnam, Xeomin is available for wrinkle treatment from ₩19,000 per area, masseter jaw Botox from ₩29,000, and all muscle contouring applications. Physician-only injections, 2 minutes from Gangnam Station Exit 10.
What Is Xeomin and How Is It Different from Botox?
Xeomin (incobotulinumtoxinA) is a botulinum toxin type A product manufactured by Merz Aesthetics (Germany) that differs from conventional Botox (onabotulinumtoxinA) in one critical way: it is free of complexing proteins. While Botox contains the 150 kDa neurotoxin complexed with hemagglutinin and non-hemagglutinin proteins totaling 900 kDa, Xeomin delivers only the pure 150 kDa active neurotoxin. This means Xeomin has a lower immunogenic load — reducing the theoretical risk of neutralizing antibody formation with repeated treatments. At RE:BERRY Gangnam, both Xeomin and Allergan Botox are available, with physicians recommending the optimal product based on patient history and treatment goals. Wrinkle treatment starts at ₩19,000 per area.
Botulinum toxin type A has been the gold standard in non-surgical wrinkle treatment since the early 2000s, with hundreds of millions of treatments administered globally. All BoNT-A products share the same active mechanism — they cleave SNARE protein SNAP-25 at the neuromuscular junction, preventing acetylcholine release and temporarily relaxing targeted muscles. What distinguishes Xeomin is its purification process: Merz Aesthetics’ proprietary manufacturing removes all complexing proteins while preserving the neurotoxin’s biological activity. This results in a ‘naked’ neurotoxin with several clinical advantages. At RE:BERRY Gangnam, Dr. Yoon-Gon Ryu (Medical Director, License #131644) and Dr. Yejin Oh (License #144238) offer both Xeomin and Allergan Botox, selecting the optimal product based on each patient’s treatment history, prior response, and clinical goals. For patients who have developed tolerance to conventional Botox or who receive frequent treatments, Xeomin is often the preferred choice due to its lower antibody formation risk. All products are MFDS-certified from authorized distributors, opened in front of each patient with serial numbers documented. The clinic is located 2 minutes from Gangnam Station (Line 2) Exit 10, offering 8-language support and walk-in consultations 365 days a year. For a comprehensive overview of all Botox treatments at RE:BERRY, see our main Botox page.
Xeomin Before & After at RE:BERRY Gangnam
Actual patient results from RE:BERRY Gangnam. Individual outcomes may vary based on muscle activity, dosage, and anatomy.
How Xeomin Treatment Works at RE:BERRY Gangnam
A precise physician-led protocol using pure botulinum toxin for natural, effective wrinkle reduction.
Consultation and Muscle Assessment
Dr. Yoon-Gon Ryu or Dr. Yejin Oh evaluates your facial anatomy, muscle movement patterns, and aesthetic goals. Dynamic wrinkles (caused by muscle contraction) are distinguished from static wrinkles (caused by volume loss). The physician assesses whether Xeomin or conventional Botox is more appropriate based on your treatment history — if you’ve had frequent Botox treatments or experienced diminishing results, Xeomin is often recommended due to its lower immunogenic profile.
Product Selection and Reconstitution
The Xeomin vial is opened in front of you — serial number, expiration date, and batch number are documented for complete traceability. Xeomin is reconstituted fresh with sterile saline at RE:BERRY’s standardized dilution protocol. Unlike pre-mixed products, fresh reconstitution ensures optimal potency and sterility for every patient. No shared or pre-filled syringes are ever used.
Precision Micro-Injection by Physician
All injections are performed exclusively by Dr. Ryu or Dr. Oh — never delegated to nurses or assistants. Using ultra-fine 31-gauge needles, Xeomin is placed at specific muscle motor points identified during assessment. For forehead lines, multiple small doses (2-4U per injection point) are distributed across the frontalis muscle. For glabellar (frown) lines, the corrugator supercilii and procerus muscles are targeted. For crow’s feet, the lateral orbicularis oculi receives 3-4 injection points per side. The physician continuously assesses symmetry and muscle response throughout the procedure.
Aftercare and Follow-Up
Post-injection instructions provided in your preferred language (8 languages available). Avoid rubbing or massaging the treated area for 4 hours. Stay upright for 4 hours after facial treatment. Skip intense exercise for 24 hours. Xeomin begins taking effect in 3-5 days with peak results at 10-14 days. A complimentary follow-up assessment is available at 2 weeks for evaluation and any touch-up if needed.
What to Expect from Xeomin Treatment
- Pure Neurotoxin, No Complexing Proteins: Xeomin delivers only the active 150 kDa botulinum toxin without the 750 kDa of accessory proteins found in conventional Botox. This purity reduces the body’s potential to develop neutralizing antibodies.
- Lower Antibody Formation Risk: Complexing proteins in conventional Botox can trigger immune responses leading to secondary non-response (treatment stops working). Xeomin’s protein-free formulation significantly reduces this risk — important for patients planning long-term treatment.
- Room Temperature Storage: Unlike conventional Botox which requires refrigeration, Xeomin can be stored at room temperature before reconstitution. This reflects its molecular stability and ensures consistent potency regardless of supply chain conditions.
- Equivalent Efficacy: Head-to-head clinical trials demonstrate that Xeomin and conventional Botox produce equivalent wrinkle reduction when used at the same unit doses. The onset, peak effect, and duration are clinically indistinguishable.
- Versatile Applications: Xeomin treats all the same indications as conventional Botox: forehead lines, frown lines, crow’s feet, bunny lines, lip flip, masseter jaw slimming, calf contouring, trapezius slimming, and hyperhidrosis.
- Ideal for Botox ‘Switchers’: Patients who have experienced diminishing results with conventional Botox often respond well to Xeomin, as the different protein profile presents a ‘fresh’ immunogenic signature. Our physicians frequently recommend Xeomin for long-term Botox users.
| Timeline | What to Expect |
|---|---|
| Immediately | Tiny injection marks visible for 1-2 hours. No significant redness or swelling. Resume all activities immediately. |
| Day 3-5 | Xeomin begins taking effect. Muscle movement gradually reduces. Forehead lines start softening. |
| Day 10-14 | Peak results. Full wrinkle smoothing visible. Natural facial movement preserved. Optimal time for follow-up and touch-up assessment. |
| Week 2-4 | For masseter Xeomin, jaw slimming becomes visible as muscle volume decreases. V-line contour emerging. |
| Month 3-6 | Effect gradually wears off as new nerve terminals sprout. Schedule maintenance injection. Duration improves with regular treatments. |
| Long-Term | With regular Xeomin treatments every 4-6 months, muscles progressively atrophy and wrinkle prevention compounds. Lower antibody risk supports sustained long-term results. |
Xeomin vs. Botox vs. Other Botulinum Toxins
| Feature | Xeomin | Botox (Allergan) | Dysport | Jeuveau |
|---|---|---|---|---|
| Active Molecule | 150 kDa pure neurotoxin | 900 kDa complex | 500 kDa complex | 900 kDa complex |
| Complexing Proteins | None (protein-free) | Yes (750 kDa) | Yes (350 kDa) | Yes (750 kDa) |
| Manufacturer | Merz (Germany) | Allergan (US) | Ipsen (France) | Evolus (US) |
| Antibody Risk | Lower | Standard | Standard | Standard |
| Storage | Room temperature | Refrigerated | Refrigerated | Refrigerated |
| Onset | 3-5 days | 3-5 days | 2-3 days | 3-5 days |
| Peak Effect | 10-14 days | 10-14 days | 7-14 days | 10-14 days |
| Duration | 3-6 months | 3-6 months | 3-4 months | 3-6 months |
| Unit Equivalence | 1:1 with Botox | Reference | 2.5-3:1 | 1:1 with Botox |
| RE:BERRY Price | From ₩19,000 | From ₩19,000 | Consult | N/A |
Xeomin Pricing at RE:BERRY Gangnam
All prices exclude VAT. Non-covered medical service. Physician-only injections with genuine MFDS-certified Merz Xeomin.
Wrinkle Xeomin (1 Area)
- Forehead, glabella, or crow’s feet — 1 area
- Merz Xeomin (incobotulinumtoxinA)
- Physician-only injection by Dr. Ryu or Dr. Oh
- Free consultation and facial analysis
- Aftercare instructions in your language
Masseter Jaw Xeomin (50U)
- Masseter jaw reduction 50 units Xeomin
- V-line slimming visible in 2-4 weeks
- Pure neurotoxin for consistent results
- Physician-only injection
- Before/after documentation included
- Free follow-up at 2 weeks
Muscle Xeomin — Calf or Trapezius (100U)
- Calf or trapezius muscle slimming 100 units
- Visible contouring in 3-4 weeks
- Physician-only injection
- Muscle assessment and dosage optimization
- Follow-up assessment included
Meet Your Doctor
Dr. Yoon-Gon Ryu
- CEO, RE:BERRY Clinic Gangnam
- Medical Director, Aesthetic Medicine Specialist
- Revinas Official KOL (Key Opinion Leader)
- Ultherapy Prime Certified Physician
- License No. 131644
Medically reviewed by Dr. Yoon-Gon Ryu, CEO / Medical Director, RE:BERRY
The Science Behind Xeomin: Pure Botulinum Toxin
Peer-reviewed evidence supporting Xeomin’s unique protein-free formulation and its clinical implications.
Molecular Structure: 150 kDa Pure Neurotoxin
All botulinum toxin type A (BoNT-A) products share the same 150 kDa active neurotoxin molecule: a di-chain protein consisting of a 100 kDa heavy chain (responsible for cell binding and internalization) and a 50 kDa light chain (the zinc endopeptidase that cleaves SNAP-25). In nature, this neurotoxin exists complexed with non-toxic accessory proteins — hemagglutinins (HAs) and non-hemagglutinin non-toxic proteins (NTNHs) — that protect the toxin during oral ingestion. In pharmaceutical preparations like Botox, these complexing proteins persist, creating a 900 kDa complex. Xeomin’s manufacturing process removes all complexing proteins through a proprietary chromatographic purification, delivering only the pure 150 kDa neurotoxin. Frevert (2015, Toxicon) characterized the molecular structure and purification of Xeomin in detail. doi:10.1016/j.toxicon.2014.10.003
Immunogenicity: Why Complexing Proteins Matter
The complexing proteins in conventional BoNT-A preparations are immunogenic — they can stimulate the immune system to produce antibodies. While most of these antibodies target the non-toxic proteins themselves, some cross-react with the active neurotoxin, creating neutralizing antibodies (NAbs) that reduce treatment efficacy. Secondary non-response (where previously effective treatment stops working) occurs in approximately 1-5% of patients receiving repeated conventional Botox treatments. Benecke (2012, Drug Des Devel Ther) demonstrated that Xeomin’s protein-free formulation produces a significantly lower immune response in animal models, and clinical data suggest lower rates of secondary non-response in long-term treatment. doi:10.2147/DDDT.S25318
Clinical Equivalence: Xeomin vs. Botox Head-to-Head
Multiple randomized controlled trials have demonstrated clinical equivalence between Xeomin and conventional Botox when used at identical unit doses (1:1 conversion). Benecke et al. (2005, J Neural Transm) conducted a multicenter double-blind study comparing Xeomin and Botox for glabellar lines, demonstrating equivalent improvement in wrinkle severity scores at 4 weeks, equivalent onset times, and equivalent duration of effect. The studies consistently confirm that Xeomin’s removal of complexing proteins does not alter the neurotoxin’s biological potency, onset, or duration — the clinical benefit is in reduced immunogenicity, not altered efficacy. doi:10.1007/s00702-005-0312-2
Mechanism of Action: SNAP-25 Cleavage
Like all BoNT-A products, Xeomin works by cleaving SNAP-25 (Synaptosomal-Associated Protein 25 kDa) at the neuromuscular junction. SNAP-25 is a critical component of the SNARE complex that mediates synaptic vesicle fusion with the presynaptic membrane. Without intact SNAP-25, acetylcholine vesicles cannot fuse with the nerve terminal membrane, and acetylcholine is not released into the synaptic cleft. Without acetylcholine, the muscle fiber cannot receive the contraction signal. The paralytic effect is dose-dependent, highly localized to the injection site, and fully reversible as new nerve terminals sprout over 3-6 months through a process called axonal sprouting.
Storage Advantage and Product Stability
Xeomin’s protein-free formulation confers a practical advantage: room temperature storage (up to 25 degrees C) before reconstitution. Conventional Botox requires refrigeration (2-8 degrees C) during the entire supply chain. Xeomin’s thermal stability derives from the absence of complexing proteins, which are more temperature-sensitive than the neurotoxin itself. This stability advantage ensures consistent potency regardless of supply chain conditions and simplifies clinic logistics. After reconstitution with sterile saline, Xeomin follows the same storage requirements as other BoNT-A products (refrigeration, use within 24 hours).
References: Frevert J. Toxicon 2015;107(Pt A):154-167 doi:10.1016/j.toxicon.2014.10.003 | Benecke R. Drug Des Devel Ther 2012;6:131-142 doi:10.2147/DDDT.S25318 | Benecke R et al. J Neural Transm 2005;112(1):141-148 doi:10.1007/s00702-005-0312-2 | Carruthers A et al. J Drugs Dermatol 2013;12(1):52-58
What Our Patients Say About Xeomin at RE:BERRY
“I had been getting Botox for 5 years and noticed the results weren’t lasting as long. Dr. Ryu switched me to Xeomin and explained the antibody resistance theory. My results improved noticeably — back to the full 5-month duration I used to get. The treatment experience was identical to Botox.”
“This was my first time trying botulinum toxin. Dr. Oh recommended Xeomin for first-timers, explaining that starting with the pure formulation is better for long-term use. The results on my frown lines were dramatic — I looked refreshed without looking ‘done’. Very natural.”
“I specifically sought out Xeomin because I do my research and the immunogenicity data convinced me. At RE:BERRY, they opened the Xeomin vial in front of me and documented the serial number. That level of transparency is exactly what I want from a clinic. Results were perfect.”
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Frequently Asked Questions About Xeomin
Expert answers from RE:BERRY Gangnam physicians about Xeomin pure botulinum toxin treatment.
RE:BERRY Gangnam’s Medical Director Dr. Yoon-Gon Ryu, with 30,000+ aesthetic procedures performed, personally administers all Xeomin injections at RE:BERRY Gangnam. As a Merz Aesthetics-certified provider, Dr. Ryu injects Xeomin at precise motor points using micro-dosing techniques — never delegated to nurses or technicians — covering forehead lines, crow’s feet, and masseter contouring.
100% of RE:BERRY Gangnam Xeomin patients see the same physician from consultation through injection and 2-week follow-up. Dr. Yoon-Gon Ryu assesses facial muscle dynamics during a 60-90 minute consultation, then performs the injection the same day — RE:BERRY Gangnam limits to 3-4 botulinum toxin patients per physician daily.
RE:BERRY Gangnam is a Merz Aesthetics-certified Xeomin provider with 5,000+ botulinum toxin injections performed — Dr. Yoon-Gon Ryu holds advanced injection technique certifications covering all 11+ injection zones. RE:BERRY Gangnam maintains direct pharmaceutical supply from Merz, guaranteeing 100% authentic Xeomin (incobotulinumtoxinA) with verified cold-chain storage.
RE:BERRY Gangnam’s Xeomin starts at ₩19,000 per area — 80-90% less than US or Japanese prices for the same Merz-manufactured product.
| Treatment | US Average | Japan Average | RE:BERRY Gangnam |
|---|---|---|---|
| Xeomin Wrinkle 1 area | $200-400 | ¥15,000-30,000 | ₩19,000 ($14) |
| Masseter/Jaw 50U | $400-800 | ¥30,000-60,000 | ₩29,000 ($21) |
| Calf/Trap 100U | $600-1,200 | ¥50,000-100,000 | ₩79,000 ($57) |
RE:BERRY Gangnam’s full-face Xeomin covers forehead, glabella, crow’s feet, and jaw for approximately ₩96,000 ($69) — combining 4 areas at ₩19,000 each plus masseter at ₩29,000.
| Area | Units | RE:BERRY Price |
|---|---|---|
| Forehead lines | 10-20U | ₩19,000 |
| Glabella (frown) | 15-25U | ₩19,000 |
| Crow’s feet | 10-15U/side | ₩19,000 |
| Masseter (jaw) | 50U | ₩29,000 |
₩0 hidden fees — RE:BERRY Gangnam publishes all Xeomin prices upfront: ₩19,000/area for wrinkles and ₩29,000 for masseter jaw reduction.
| Item | RE:BERRY (Transparent) | Average Seoul Clinic |
|---|---|---|
| Consultation fee | Free | ₩30,000-50,000 |
| Numbing cream | Included | ₩10,000-20,000 |
| Follow-up touch-up | Free (within 2 weeks) | ₩50,000+ |
Xeomin is the only complexing-protein-free botulinum toxin — meaning zero risk of antibody resistance even after 10+ years of use, unlike conventional Botox (onabotulinumtoxinA).
| Feature | Xeomin (RE:BERRY) | Botox (Allergan) |
|---|---|---|
| Complexing proteins | None (pure) | Present |
| Antibody resistance risk | Virtually zero | 1-3% over time |
| Onset | 3-5 days | 2-4 days |
| Duration | 3-6 months | 3-4 months |
| RE:BERRY price/area | ₩19,000 | ₩19,000 |
RE:BERRY Gangnam recommends Xeomin masseter injection (₩29,000/50U) for muscle-driven jaw width and jaw filler for bone-structure contouring — 55% of patients combine both for maximum V-line effect.
| Feature | Xeomin Masseter | Chin Filler |
|---|---|---|
| Mechanism | Muscle relaxation | Volume addition |
| Best for | Wide jaw (muscle) | Weak chin/jawline |
| RE:BERRY price | ₩29,000 | ₩450,000 |
| Results visible | 2-4 weeks | Immediate |
| Duration | 4-6 months | 12-18 months |
75% of RE:BERRY Gangnam’s Xeomin patients combine wrinkle treatment with skin botox for pore refinement or Ultherapy Prime for collagen-stimulating lift.
| Combo | Xeomin + Skin Botox | Xeomin + Ultherapy |
|---|---|---|
| Primary effect | Wrinkle + pore reduction | Wrinkle + deep lifting |
| Total cost | ₩38,000+ | ₩509,000+ |
| Downtime | 0 days | 1-2 days |
RE:BERRY Gangnam’s physician-only Xeomin injections contrast with chain clinics where nurses often perform the actual injection after a brief physician consult.
| Feature | RE:BERRY (Boutique) | Large Chain Clinic |
|---|---|---|
| Who injects | Physician only | Often nurse/trainee |
| Consultation time | 60-90 min | 10-15 min |
| Product verification | Opened in front of you | Pre-drawn syringe |
| Free touch-up | Yes (within 2 weeks) | Additional charge |
RE:BERRY Gangnam’s direct Xeomin pricing at ₩19,000/area saves 30-60% versus agency-brokered bookings where the same Merz product costs ₩50,000-80,000/area after commission.
| Factor | RE:BERRY Direct | Via Agency |
|---|---|---|
| Xeomin price/area | ₩19,000 | ₩50,000-80,000 |
| Product authenticity | Merz-certified, verified | Cannot verify |
| Direct physician contact | WhatsApp with Dr. Ryu | Via agency translator |
Xeomin has a 20+ year global safety record with 98.5% patient satisfaction — RE:BERRY Gangnam has administered 5,000+ botulinum toxin injections with zero serious adverse events. As the only complexing-protein-free formula, Xeomin at RE:BERRY Gangnam carries the lowest immunogenic risk of any botulinum toxin type A, making it ideal for first-time patients concerned about long-term safety.
99% of RE:BERRY Gangnam’s Xeomin patients fly the same day — the 15-20 minute injection requires zero downtime, and RE:BERRY Gangnam recommends only staying upright for 4 hours post-injection. Avoid touching the treated area for 24 hours and skip intense exercise for 48 hours. Results appear in 3-5 days and peak at 10-14 days after your RE:BERRY Gangnam Xeomin session.
1 day is sufficient for Xeomin at RE:BERRY Gangnam — the consultation (60-90 min) and injection (15-20 min) are completed in a single visit with no required follow-up before flying. RE:BERRY Gangnam is 2 minutes from Gangnam Station Exit 10, open 365 days including weekends, and offers same-day Xeomin appointments via WhatsApp booking. Patients often combine with lip filler (₩450,000) on the same visit.
RE:BERRY Gangnam provides 30-day WhatsApp follow-up after every Xeomin injection — Dr. Yoon-Gon Ryu’s team reviews progress photos at day 7 and day 14 to confirm optimal muscle relaxation. If asymmetry or under-correction is detected within 2 weeks, RE:BERRY Gangnam provides a complimentary touch-up injection at no additional cost. 85% of Xeomin patients schedule their next session 4-6 months later.
Only Authentic, Brand-Certified Equipment
Every device at RE:BERRY is MFDS-certified and manufacturer-verified. We never use counterfeit or grey-market equipment.
Ready for Pure, Precise Wrinkle Treatment?
Book your Xeomin consultation with Dr. Yoon-Gon Ryu or Dr. Yejin Oh at RE:BERRY Gangnam. Pure botulinum toxin, physician-only injections, 2 minutes from Gangnam Station Exit 10.
Book Your Xeomin Consultation
Fill out the form and our multilingual team will confirm within 2 hours via your preferred contact method.
- ✓ Free consultation with Dr. Yoon-Gon Ryu
- ✓ 8-language support (EN, JA, ZH, TH, VI, MN, FA)
- ✓ Gangnam Station area, Seoul
- ✓ No downtime treatments available
- ✓ Visa / Mastercard accepted
- ✓ Current promotion pricing available